Please find below the eighteenth Ximbio product update. This month’s mailer details fifteen new monoclonal antibodies available for licence or purchase.

For licensing and sales enquiries please email: [email protected] or call +44 (0)20 3469 6449.

Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed at www.ximbio.com

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Applications: IHC  IF  WB
Reactivity: Human Mouse
The IL21 receptor is expressed in cells lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. IL21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells.

 

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Applications: ELISA IF WB
Reactivity: Human Mouse
Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelget-Huët anomaly featuring hypolobulated granulocyte nuclei

 

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Applications: IHC  IF  WB
Reactivity: Human
Lamins A and C are major components of the nuclear lamina, a thin protein meshwork located at the nuclear face of the nuclear envelope (NE). The lamina provides structural integrity to the NE and is involved in many other aspects of nuclear biology including transcription and chromatin organization.

 

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Applications: IHC  IF  WB
Reactivity: Human Mouse
Lamins A and C are major components of the nuclear lamina, a thin protein meshwork located at the nuclear face of the nuclear envelope (NE). The lamina provides structural integrity to the NE and is involved in many other aspects of nuclear biology including transcription and chromatin organization.
 
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Applications: IF  WB
Reactivity: E. Coli
E.coli BirA is a well-characterized multifunctional protein that either catalyses the transfer of biotin to biotin carboxyl carrier protein (BCCP), a acetyl-CoA carboxylase subunit or, alternatively, binds to the biotin operator resulting in transcriptional repression of the biotin operon. A mutant BirA (R118G) shows loss of DNA binding ability and promiscuity of substrate biotinylation. These properties of BirA R118G were used to develop an in vivo proximity labelling technique that identifies potential interacting proteins (BioID).
 
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Applications: IF WB 
Reactivity: E.coli
E.coli BirA is a well-characterized multifunctional protein that either catalyses the transfer of biotin to biotin carboxyl carrier protein (BCCP), a acetyl-CoA carboxylase subunit or, alternatively, binds to the biotin operator resulting in transcriptional repression of the biotin operon. A mutant BirA (R118G) shows loss of DNA binding ability and promiscuity of substrate biotinylation. These properties of BirA R118G were used to develop an in vivo proximity labelling technique that identifies potential interacting proteins (BioID).
 
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Applications: IF WB
Reactivity: Aquifex aeolicus
The SS QD1 monoclonal antibodies were generated to support the recent developments in the BioID, a method that can be used to detect potential interacting proteins. In the BioID method, a promiscuous biotin protein ligase (BPL) is fused to a protein of interests and expressed in vivo where it biotinylates proteins in a proximity-dependent manner. The biotinylated proteins can then be affinity purified and identified by mass spectrometry
 
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Applications: IF WB
Reactivity: Aquifex aeolicus
The SS 3A5-E2 monoclonal antibodies were generated to support the recent developments in the BioID, a method that can be used to detect potential interacting proteins . In the BioID method, a promiscuous biotin protein ligase (BPL) is fused to a protein of interests and expressed in vivo where it biotinylates proteins in a proximity-dependent manner. The biotinylated proteins can then be affinity purified and identified by mass spectrometry.
 
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Applications: IF WB
Reactivity: Human Mouse Rat
A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-domain proteins of the outer nuclear membrane (ONM). In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5).
 
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Applications: IF  WB
Reactivity: Mouse ; Rat
A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-domain proteins of the outer nuclear membrane (ONM). In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5).

 

icon-01_Antibodies.jpg
Applications: IF  WB
Reactivity: Human
In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.
 
icon-01_Antibodies.jpg
Applications: IF  WB
Reactivity: Human
In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.
 
 icon-01_Antibodies.jpg
Applications: IF  WB
Reactivity: Mouse Rat
In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.
 
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Applications: FACS  WB
Reactivity: Human
C-kit, also known as CD117, is expressed on the surface of hematopoietic stem cells. C-kit is a receptor tyrosine kinase that is overexpressed in > 70% of gastrointestinal stromal tumors (GISTs).
 
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Applications: FACS  WB
Reactivity: Human
C-kit, also known as CD117, is expressed on the surface of hematopoietic stem cells. C-kit is a receptor tyrosine kinase that is overexpressed in > 70% of gastrointestinal stromal tumors (GISTs).
 

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