New Antibodies from Ximbio

Please find below our ninth Ximbio product update. This month’s mailer details monoclonal antibodies new to Ximbio developed at the Babraham Institute, CRUK London Research Institute, the Universities of Birmingham, Bristol and Leicester, University College London and UbiQ.

Ximbio introduces 15 new monoclonal antibodies available for licence or purchase.
 
For licensing and sales enquiries please email: enquiries@ximbio.com

Or call +44 (0)20 3469 6449.

Technical datasheets for Ximbio’s expanding research tool portfolio can be accessed at www.ximbio.com

	Anti-DMC1 [5B10/2] Applications: IHC IP WB Reactivity: Human PMIDs: 10562567 May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
	Anti-S100a9, Polyclonal [NH6] Applications: WB FACS Reactivity: Mouse Together with heterodimeric partner S100a8, S100a9 is a major biomarker of inflammation both in released form in serum and through increased expression in epithelial tissue and many tumour models.
	Anti-S100a8, Polyclonal [NH9] Applications: WB FACS Reactivity: Mouse PMIDs: 22016186, 12640137 Together with heterodimeric partner S100a9, S100a8 is a major biomarker of inflammation both in released form in serum and through increased expression in epithelial tissue and in many tumour models.
	Anti-S100A12, Polyclonal [NH4] Applications: WB IP IHC Reactivity: Human PMID: 10973813 Major biomarker of inflammation eg. inflammatory bowel disease, rheumatoid arthritis. Serves a ligand for RAGE (receptor for advanced glycation products) with role in tumour growth and wound healing.
	Anti-GFAP [FD19-9] Applications: IHC IF Reactivity: Human PMID:17645461, 16621008, 6202990 GFAP is specifically found in astroglia, a cell type which is highly responsive to neurologic insults. Astrogliosis is found to be a result of mechanical trauma, AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP expression. GFAP is an immunohistochemical marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system.
	Anti-BORIS [20B11] Applications: ChIP ELISA IHC IF IP WB Reactivity: Human BORIS protein has been identified as Cancer-Testis Antigen (CTA) with testis-specific paralogue of the CCCTC-binding factor. Recent studies have demonstrated that d BORIS is directly responsible for the transcriptional activation of TSP50 (testes-specific protease 50).
	Anti-Lewis y/b hapten [NCRC37] Applications: ELISA FACS IHC Fn Reactivity: Human PMIDs: 16740730, 7507082 The antibody, NCRC37, is a pan-reactive, anti-colorectal tumour antibody and binds strongly to coloretal tumour cells and to post mortem cryopreserved tissues of brain, spleen, heat, lung, kidney, testes, oesophagus or stomach.
	Anti-MuC3 [NCRC74] Applications: ELISA Reactivity: Human Mucins are a family of highly glycosylated, large molecular weight glycoproteins which are associated with many epithelial cells. Muc3 is a major glycoprotein component in a variety of mucus gels, which at a variety of musocal surfaces are thought to provide a protective barrier against particles and infectious agents.
	Anti-CD11b [2LPM19c] Applications: FACS IHC Reactivity: Human PMIDs: 11031208, 7673724, 7679388 CD11b, also known as Integrin alpha M, is found in neutrophils, monocytes and Natural Killer (NK) cells. CD11b plays a role in chemotaxis, apoptosis and phagocytosis.  It is absent in Leukocyte Adhesion Deficiency (LAD-1) and is a target for anti-inflammatory drug therapies.
	Anti-FANCB [M38P3E10] Applications: ELISA IHC WB Reactivity: Human FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
	Anti-PDL2 (soluble form) [Z64P2D3*H4]Applications: ELISA IHC WB Reactivity: Human PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
	Anti-ELOVL Fatty Acid Elongase 7 [Z26] Applications: ELISA IHC WB Reactivity: Human ELOVL Fatty Acid Elongase 7 (ELOVL7) is a condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs.
	Anti-WFDC5-WAP [M47-P2D5] Applications: ELISA IHC WB Reactivity: Human WFDC5 is a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, whereas WFDC5 contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.